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Interestingly, another study using the lung cancer model observed a downregulated expression of 26S proteasome in lung cancer stem cells

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Nrf2 is a major regulator of the cellular oxidative stress response and maintenance of redox homeostasis ( 2.3 Cisplatin induces mitochondrial dysfunction When cisplatin enters the mitochondria, it acts directly on the inner mitochondrial membrane, leading to the impairment of the function of the electron transport chain, the reduction of ATP production and the induction of ROS generation ( Dysfunctional mitochondria release into the cytoplasm, it binds to with Apaf-1, triggering caspase-9, caspase-3 related cascade reactions that lead to apoptosis (Figure 2)

It has the potential to improve focus and memory enhancement, which is inspiring the international players to establish their footprint in the country